Skin-to-skin care in preterm infants receiving respiratory support does not lead to physiological instability

by:Beauty Spirit     2020-08-08
Skin provided-to-skin care (SSC)
This is the standard practice for many neonatal intensive care units for premature infants.
Report on the contradiction between the stability of oxygen saturation (SpO2)
During SSC, this may cause obstacles to the wider implementation of SSC for infants receiving respiratory support.
Regional Brain oxygen (rcO2)
Use near-
Infrared spectrum can be used as an alternative parameter for brain oxygen transport and consumption.
We assume that rcO2 during SSC is similar to standard care for premature infants receiving respiratory support.
Design prospective observation
Learning from inferiority
A single tertiary Perinatal Center is set up in Australia.
40 premature infants (median (IQR)of 27. 6 (26. 0–28. 9)
Week of pregnancy)
Study of respiratory support for 8 days (5–18).
A 90-minute intervention of the SSC was performed, with the baby in the incubator acting as their own control.
Parents and caregivers turned a blind eye to the results.
The main results measured the average difference in rcO2 between SSC and incubator care;
And heart rate (HR)
, Sp02, fraction of oxygen inhalation (FiO2)
And temperature, using paired t-test.
Results rcO2 was similar during SSC (mean (SD)74. 9 (6. 5)%)
% Compared with incubator care (74. 7 (6. 1)
%, Average difference (95% CI)0. 2 (−0. 8 to 1. 1)%, p=0. 71).
Throughout the cohort, no significant clinical differences in HR, sp02, FiO2, or temperature were observed through respiratory support mode (
Mechanical ventilation of trachea catheter, continuous positive airway pressure, high
Flow nasal catheter).
Conclusion SSC and incubator care have no difference in brain oxygen and other physiological measures in ventilated premature infants.
Trial registration number 12615000959572.
Purpose to provide skinto-skin care (SSC)
This is the standard practice for many neonatal intensive care units for premature infants.
Report on the contradiction between the stability of oxygen saturation (SpO2)
During SSC, this may cause obstacles to the wider implementation of SSC for infants receiving respiratory support.
Regional Brain oxygen (rcO2)
Use near-
Infrared spectrum can be used as an alternative parameter for brain oxygen transport and consumption.
We assume that rcO2 during SSC is similar to standard care for premature infants receiving respiratory support.
Design prospective observation
Learning from inferiority
A single tertiary Perinatal Center is set up in Australia.
40 premature infants (median (IQR)of 27. 6 (26. 0–28. 9)
Week of pregnancy)
Study of respiratory support for 8 days (5–18).
A 90-minute intervention of the SSC was performed, with the baby in the incubator acting as their own control.
Parents and caregivers turned a blind eye to the results.
The main results measured the average difference in rcO2 between SSC and incubator care;
And heart rate (HR)
, Sp02, fraction of oxygen inhalation (FiO2)
And temperature, using paired t-test.
Results rcO2 was similar during SSC (mean (SD)74. 9 (6. 5)%)
% Compared with incubator care (74. 7 (6. 1)
%, Average difference (95% CI)0. 2 (−0. 8 to 1. 1)%, p=0. 71).
Throughout the cohort, no significant clinical differences in HR, sp02, FiO2, or temperature were observed through respiratory support mode (
Mechanical ventilation of trachea catheter, continuous positive airway pressure, high
Flow nasal catheter).
Conclusion SSC and incubator care have no difference in brain oxygen and other physiological measures in ventilated premature infants.
Trial registration number 12615000959572.
The German Institute of Research funded the Fellowship for Dr. Laila LorenzoDFG-grant nr. LO 2162/1-1).
National Commission for Health and Medical Research (NHMRC)
Grant Professor Peter G. Davis (App ID 1059111)
Dr. Omar F. kamlin (App ID 1073533)
Associate Professor Zheng Jenny (App 1053787)
Associate Professor Susan JacobsApp 1073103)
, NHMRC Project funding for PGD, COFK, JAD, Australia.
No one declared a competitive interest.
The patient obtained agrees with the parent/guardian.
Ethical approval of the Human Research and Ethics Committee of the Royal Women\'s Hospital.
Uncommissioned source and peer review;
External peer review.
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